Top 100 Most Disruptive

The 100 most-disruptive papers by the Funk & Owen-Smith CD (disruption) index, which measures how much a paper redirected the field away from prior work.

Curated by · Professor of Surgery, Department of Colon & Rectal Surgery, Cleveland Clinic · Corpus last refreshed · Publications

Ranked from the ulcerative-colitis surgical and high-acuity literature.

The disruption index is unreliable for papers published within the last 5 years. The forward-citation window is too short to score them, so recent papers are excluded from this ranking. A research reference for clinicians and trainees, not treatment advice.

#PaperAltmetricCD index
1Chronic ulcerative colitis associated with malignant disease. 1928.
Bargen JA · 1994 · Dis Colon Rectum
+0.690
20 cites
2Laparoscopic total proctocolectomy with creation of ileostomy for ulcerative colitis: report of two cases.
Peters · 1992 · J Laparoendosc Surg
+0.496
63 cites
3Ulcerative colitis with relative sparing of the rectum. Clinical features, histology, and prognosis.
Spiliadis · 1987 · Dis Colon Rectum
+0.356
48 cites
4An analysis of 10218 ulcerative colitis cases in China.
Jiang XL · 2002 · World J Gastroenterol
+0.296
134 cites
5An Update on the Medical Management of Inflammatory Pouch Complications
Quinn · 2020 · Am J Gastroenterol
+0.221
30 cites
6Predicting Outcomes in Pediatric Ulcerative Colitis for Management Optimization: Systematic Review and Consensus Statements From the Pediatric Inflammatory Bowel Disease-Ahead Program.
Orlanski-Meyer · 2021 · Gastroenterology
+0.218
48 cites
7Treatment of colorectal and ileoanal anastomotic sinuses
Whitlow · 1997 · Dis Colon Rectum
+0.166
55 cites
8Course of ulcerative colitis: analysis of changes in disease activity over years.
Langholz · 1994 · Gastroenterology
+0.142
526 cites
9Fate of the rectal mucosa after rectal mucosectomy and ileoanal anastomosis.
Heppell · 1983 · Dis Colon Rectum
+0.121
105 cites
10Dysplasia in inflammatory bowel disease: standardized classification with provisional clinical applications.
Riddell · 1983 · Hum Pathol
+0.113
1,590 cites
11Cyclosporine in severe ulcerative colitis refractory to steroid therapy.
Lichtiger · 1994 · N Engl J Med
+0.110
1,435 cites
12Serum antibodies to Bacteroides species in chronic inflammatory bowel disease.
Tvede · 1983 · Scand J Gastroenterol
+0.109
42 cites
13Subtotal colectomy for ulcerative colitis: complications related to the rectal remnant.
Carter F · 1991 · Dis Colon Rectum
+0.101
75 cites
14Active ulcerative colitis associated with low prevalence of Blastocystis and Dientamoeba fragilis infection.
Petersen AM · 2013 · Scand J Gastroenterol
+0.090
82 cites
15The OMGE multinational inflammatory bowel disease survey 1976-1986. A further report on 3175 cases.
Myren J · 1988 · Scand J Gastroenterol Suppl
+0.084
22 cites
16Inflammatory bowel disease.
Hyams Jeffrey · 2005 · Pediatr Rev
+0.084
26 cites
17Laparoscopic surgery for inflammatory bowel disease
Liu · 1995 · Am Surg
+0.078
45 cites
18Readmissions after colorectal surgery cannot be predicted.
Azimuddin · 2001 · Dis Colon Rectum
+0.072
77 cites
19Fecal Microbiota Transplant for Recurrent Clostridium difficile Infection in Pediatric Inflammatory Bowel Disease.
Cho · 2019 · J Pediatr Gastroenterol Nutr
+0.071
23 cites
20Amino acid losses in ileostomy fluid on a protein-free diet.
Fuller MF · 1994 · Am J Clin Nutr
+0.064
63 cites
21The fate of the rectal stump after subtotal colectomy for ulcerative colitis.
Oakley · 1985 · Dis Colon Rectum
+0.062
47 cites
22Incidence and prevalence of ulcerative colitis in Copenhagen county from 1962 to 1987.
Langholz E · 1991 · Scand J Gastroenterol
+0.062
218 cites
23Clinical outcome of ulcerative colitis in children.
Hyams · 1996 · J Pediatr
+0.058
127 cites
24An assessment of inflammation in the reservoir after restorative proctocolectomy with ileoanal ileal reservoir
Moskowitz · 1986 · Int J Colorectal Dis
+0.058
300 cites
25Combination therapy in inflammatory bowel disease - from traditional immunosuppressors towards the new paradigm of dual targeted therapy.
Privitera G · 2021 · Autoimmun Rev
+0.056
56 cites
26Laparoscopic total abdominal colectomy. A prospective trial
Wexner · 1992 · Dis Colon Rectum
+0.050
191 cites
27Sexual function in women after proctocolectomy
Metcalf · 1986 · Ann Surg
+0.049
82 cites
28A surgical subspecialist enhances general surgical operative experience
Galandiuk · 1995 · Arch Surg
+0.049
25 cites
29Ileal pouch-anal anastomosis without temporary, diverting ileostomy
Metcalf · 1986 · Dis Colon Rectum
+0.047
54 cites
30Long term prognosis in ulcerative colitis--based on results from a regional patient group from the county of Copenhagen.
Hendriksen · 1985 · Gut
+0.047
219 cites
31Ulcerative colitis and colorectal cancer. A population-based study.
Ekbom · 1990 · N Engl J Med
+0.046
1,440 cites
32Results of the pelvic-pouch procedure in patients with Crohn's disease.
Deutsch A · 1991 · Dis Colon Rectum
+0.044
132 cites
33Development and Validation of Risk Matrices Concerning Ulcerative Colitis Outcomes-Bayesian Network Analysis.
Magro · 2019 · J Crohns Colitis
+0.041
20 cites
34Treatment of steroid refractory inflammatory bowel disease (IBD) with mycophenolate mofetil (MMF).
Florin TH · 1998 · Aust N Z J Med
+0.038
25 cites
35Relationship of backwash ileitis to ileal pouchitis after ileal pouch-anal anastomosis
Gustavsson · 1987 · Dis Colon Rectum
+0.033
71 cites
36Pouchitis associated with primary cytomegalovirus infection
Moonka · 1998 · Am J Gastroenterol
+0.030
68 cites
37Very low intraluminal colonic pH in patients with active ulcerative colitis.
Fallingborg · 1993 · Dig Dis Sci
+0.030
175 cites
38Predicting the functional result of anastomoses to the anus: the paradox of preoperative anal resting pressure
Church · 1993 · Dis Colon Rectum
+0.029
26 cites
39Long-term ileostomy complications in patients with ulcerative colitis and Crohn's disease.
Carlstedt · 1987 · Int J Colorectal Dis
+0.029
57 cites
40Sexual dysfunction following proctocolectomy for benign disease of the colon and rectum
Bauer · 1983 · Ann Surg
+0.027
48 cites
41Wernicke's encephalopathy during total parenteral nutrition: observation in one case.
Mattioli S · 1988 · JPEN J Parenter Enteral Nutr
+0.026
21 cites
42Prevention of postoperative abdominal adhesions by a sodium hyaluronate-based bioresorbable membrane: a prospective, randomized, double-blind multicenter study
Becker · 1996 · J Am Coll Surg
+0.026
545 cites
43Life-table analysis of stomal complications following ileostomy.
Leong · 1994 · Br J Surg
+0.026
132 cites
44Absorption of an oral contraceptive gestagen in ulcerative colitis before and after proctocolectomy and construction of a continent ileostomy
Nilsson · 1985 · Contraception
+0.025
29 cites
45An enema formulation of alicaforsen, an antisense inhibitor of intercellular adhesion molecule-1, in the treatment of chronic, unremitting pouchitis
Miner · 2004 · Aliment Pharmacol Ther
+0.024
108 cites
46Psychologic response to colectomy.
Druss · 1968 · Arch Gen Psychiatry
+0.024
66 cites
47Usefulness of valproate sodium for treatment of incontinence after ileoanal anastomosis.
Kusunoki · 1990 · Surgery
+0.023
29 cites
48Mucosal healing in inflammatory bowel disease: results from a Norwegian population-based cohort.
Frøslie · 2007 · Gastroenterology
+0.023
938 cites
49Gynaecological problems related to anatomical changes after conventional proctocolectomy and ileostomy
Wikland · 1990 · Int J Colorectal Dis
+0.023
61 cites
50Pediatric ileal pouch-anal anastomosis: functional outcomes and quality of life
Stavlo · 2003 · J Pediatr Surg
+0.021
38 cites
51Axonal damage in Crohn's disease is frequent, but non-specific.
Brewer DB · 1990 · J Pathol
+0.020
22 cites
52Coffee and alcohol use and the risk of ulcerative colitis.
Boyko EJ · 1989 · Am J Gastroenterol
+0.019
38 cites
53A new treatment for toxic megacolon.
Kuroki K · 1998 · Lancet
+0.019
24 cites
54Altered tight junction structure contributes to the impaired epithelial barrier function in ulcerative colitis.
Schmitz · 1999 · Gastroenterology
+0.019
469 cites
55Submucosal accumulation of fat in inflammatory bowel disease: CT/pathologic correlation.
Jones B · 1986 · J Comput Assist Tomogr
+0.018
84 cites
56Inflammatory bowel disease in the United States from 1998 to 2005: has infliximab affected surgical rates?
Cannom Rebecca · 2009 · Am Surg
+0.018
50 cites
57Surgery for ulcerative colitis in the era of the pouch: the St Mark's Hospital experience
Melville · 1994 · Gut
+0.017
62 cites
58Clinical outcome of ulcerative proctitis in children.
Hyams · 1997 · J Pediatr Gastroenterol Nutr
+0.016
26 cites
59Effect of dietary inulin supplementation on inflammation of pouch mucosa in patients with an ileal pouch-anal anastomosis
Welters · 2002 · Dis Colon Rectum
+0.016
177 cites
60Work disability in inflammatory bowel disease patients 10 years after disease onset: results from the IBSEN Study.
Høivik · 2013 · Gut
+0.016
214 cites
61A cluster of rotavirus enteritis in adult transplant recipients.
Stelzmueller I · 2005 · Transpl Int
+0.015
30 cites
62Mucosal healing in ulcerative colitis: pathophysiology and pharmacology.
Seidelin · 2013 · Adv Clin Chem
+0.015
30 cites
63Proctocolectomy and ileoanal anastomosis.
Beart · 1988 · World J Surg
+0.015
26 cites
64Factors affecting colectomy rate in ulcerative colitis: an epidemiologic study.
Leijonmarck · 1990 · Gut
+0.015
154 cites
65Omental transposition for low pelvic anastomoses
Topor · 2001 · Am J Surg
+0.014
20 cites
66Epidemiology and natural history of inflammatory bowel diseases.
Cosnes · 2011 · Gastroenterology
+0.014
1,659 cites
67Successful childbirth after restorative proctocolectomy with pelvic ileal reservoir
Pezim · 1984 · Br J Surg
+0.014
27 cites
68Modified two-stage ileal pouch-anal anastomosis: equivalent outcomes with less resource utilization
Swenson · 2005 · Dis Colon Rectum
+0.014
57 cites
69Surgery for acute ulcerative colitis and toxic megacolon during pregnancy.
Cooksey · 1985 · Br J Surg
+0.013
25 cites
70Fate of the pouch in 151 pediatric patients after ileal pouch anal anastomosis
Alexander · 2003 · J Pediatr Surg
+0.012
99 cites
71What are the differences in body image between patients with a conventional stoma compared with those who have had a conventional stoma followed by a continent pouch?
Salter · 1992 · J Adv Nurs
+0.012
37 cites
72Marital status and sexual adjustment after colectomy. Results in 178 patients operated on for ulcerative colitis.
Grüner · 1977 · Scand J Gastroenterol
+0.012
46 cites
73Abdominal Emergencies in Inflammatory Bowel Disease.
Goldstone RN · 2019 · Surg Clin North Am
+0.012
27 cites
74Hemodynamics in the prone jackknife position during surgery
Hatada · 1991 · Am J Surg
+0.012
20 cites
75VSL#3 can prevent ulcerative colitis-associated carcinogenesis in mice.
Wang CS · 2018 · World J Gastroenterol
+0.012
114 cites
76Ileal pouch-anal anastomosis without ileostomy
Galandiuk · 1991 · Dis Colon Rectum
+0.012
69 cites
77Acute surgical emergencies in inflammatory bowel disease.
Berg · 2002 · Am J Surg
+0.011
95 cites
78Surgical therapy for ulcerative colitis and Crohn's disease.
Becker · 1999 · Gastroenterol Clin North Am
+0.011
86 cites
79Outcome of "indeterminant" colitis following ileal pouch-anal anastomosis
Pezim · 1989 · Dis Colon Rectum
+0.011
103 cites
80Paraileostomy hernia: a clinical and radiological study.
Williams · 1990 · Br J Surg
+0.011
76 cites
81Hospitalization, surgery, and readmission rates of IBD in Canada: a population-based study.
Bernstein · 2006 · Am J Gastroenterol
+0.011
122 cites
82Impact of Clostridium difficile on inflammatory bowel disease.
Issa · 2007 · Clin Gastroenterol Hepatol
+0.011
452 cites
83Similar functional results after restorative proctocolectomy in patients with familial adenomatous polyposis and mucosal ulcerative colitis
Tjandra · 1993 · Am J Surg
+0.011
84 cites
84Changes in extent of ulcerative colitis: a study on the course and prognostic factors.
Langholz · 1996 · Scand J Gastroenterol
+0.010
180 cites
85Restorative proctocolectomy in patients older than fifty years
Bauer · 1997 · Dis Colon Rectum
+0.010
45 cites
86Diagnostic standards in the pathology of inflammatory bowel disease.
Loddenkemper · 2009 · Dig Dis
+0.010
21 cites
87Anal complications after restorative proctocolectomy (J-pouch)
Rossi · 2002 · Am Surg
+0.010
23 cites
88Stapled ileo-anal anastomosis: a technique to avoid mucosal proctectomy in the ileal pouch operation
Heald · 1986 · Br J Surg
+0.010
169 cites
89HIV associated cytomegalovirus colitis as a mimic of inflammatory bowel disease.
Roskell · 1995 · Gut
+0.010
22 cites
90Ulcerative colitis
Ordás · 2012 · Lancet
+0.009
1,751 cites
91High circulating concentrations of interleukin-6 in active Crohn's disease but not ulcerative colitis.
Mahida · 1991 · Gut
+0.009
169 cites
92The critical level for preservation of continence in the ileoanal anastomosis.
Martin · 1985 · J Pediatr Surg
+0.009
62 cites
93Cyclosporin A treatment of steroid-refractory ulcerative colitis during pregnancy: report of two cases.
Reindl W · 2007 · Gut
+0.009
24 cites
94Manometric analysis of anal sphincter damage after ileal pouch-anal anastomosis
Kroesen · 1999 · Int J Colorectal Dis
+0.009
28 cites
95Crohn's disease, ulcerative colitis or indeterminate colitis--how important is it to differentiate?
Geboes · 2001 · Acta Gastroenterol Belg
+0.009
29 cites
96Closure of loop ileostomy after restorative proctocolectomy
Lewis · 1990 · Ann R Coll Surg Engl
+0.008
41 cites
97Radiology of ileal pouch-anal anastomosis: normal findings, examination pitfalls, and complications
Alfisher · 1997 · Radiographics
+0.008
26 cites
98Thoracic versus lumbar epidural anesthesia's effect on pain control and ileus resolution after restorative proctocolectomy
Scott · 1996 · Surgery
+0.008
48 cites
99Recent trends in the surgical management of inflammatory bowel disease
Roses · 2008 · World J Gastroenterol
+0.008
26 cites
100An audit of restorative proctocolectomy
Keighley · 1993 · Gut
+0.008
58 cites