Evidence-based

References

Every clinical statement on ucolitis.org is grounded in the published medical literature. The references below are the peer-reviewed sources cited throughout this site, listed in order of first appearance. Each was harvested from the site's own citations and verified against the U.S. National Library of Medicine (PubMed). Last verified July 2026.

  1. Toward an integrated clinical, molecular and serological classification of inflammatory bowel disease: report of a Working Party of the 2005 Montreal World Congress of Gastroenterology. Silverberg MS. Can J Gastroenterol 2005. PMID: 16151544.
  2. Ulcerative colitis. Ordás I. Lancet 2012. PMID: 22914296.
  3. Cortisone in ulcerative colitis; final report on a therapeutic trial. TRUELOVE SC. Br Med J 1955. PMID: 13260656.
  4. Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. Schroeder KW. N Engl J Med 1987. PMID: 3317057.
  5. Developing an instrument to assess the endoscopic severity of ulcerative colitis: the Ulcerative Colitis Endoscopic Index of Severity (UCEIS). Travis SP. Gut 2012. PMID: 21997563.
  6. ACG Clinical Guideline: Ulcerative Colitis in Adults. Rubin DT. Am J Gastroenterol 2019. PMID: 30840605.
  7. Infliximab for induction and maintenance therapy for ulcerative colitis. Rutgeerts P. N Engl J Med 2005. PMID: 16339095.
  8. Vedolizumab as induction and maintenance therapy for ulcerative colitis. Feagan BG. N Engl J Med 2013. PMID: 23964932.
  9. Tofacitinib as Induction and Maintenance Therapy for Ulcerative Colitis. Sandborn WJ. N Engl J Med 2017. PMID: 28467869.
  10. Ustekinumab as Induction and Maintenance Therapy for Ulcerative Colitis. Sands BE. N Engl J Med 2019. PMID: 31553833.
  11. Ciclosporin versus infliximab in patients with severe ulcerative colitis refractory to intravenous steroids: a parallel, open-label randomised controlled trial. Laharie D. Lancet 2012. PMID: 23063316.
  12. Infliximab versus ciclosporin for steroid-resistant acute severe ulcerative colitis (CONSTRUCT): a mixed methods, open-label, pragmatic randomised trial. Williams JG. Lancet Gastroenterol Hepatol 2016. PMID: 27595142.
  13. The American Society of Colon and Rectal Surgeons Clinical Practice Guidelines for the Surgical Management of Ulcerative Colitis. Holubar SD. Dis Colon Rectum 2021. PMID: 33853087.
  14. European evidence based consensus on surgery for ulcerative colitis. Øresland T. J Crohns Colitis 2015. PMID: 25304060.
  15. Ileal pouch anal anastomosis: analysis of outcome and quality of life in 3707 patients. Fazio VW. Ann Surg 2013. PMID: 23299522.
  16. AGA Clinical Practice Guideline on the Management of Pouchitis and Inflammatory Pouch Disorders. Barnes EL. Gastroenterology 2024. PMID: 38128971.
  17. Threefold increased risk of infertility: a meta-analysis of infertility after ileal pouch anal anastomosis in ulcerative colitis. Waljee A. Gut 2006. PMID: 16772310.
  18. SCENIC international consensus statement on surveillance and management of dysplasia in inflammatory bowel disease. Laine L. Gastroenterology 2015. PMID: 25702852.
  19. The risk of colorectal cancer in ulcerative colitis: a meta-analysis. Eaden JA. Gut 2001. PMID: 11247898.
  20. The management of the hospitalized ulcerative colitis patient: the medical-surgical conundrum. Levy LC. Curr Opin Gastroenterol 2020. PMID: 32487850.
  21. Acute severe ulcerative colitis: defining the precise moment for colectomy. Kotze PG. Expert Rev Gastroenterol Hepatol 2025. PMID: 39753508.
  22. Factors Associated With Response to Rescue Therapy in Acute Severe Ulcerative Colitis. Li Wai Suen CFD. Inflamm Bowel Dis 2024. PMID: 37725044.
  23. The use of infliximab for treatment of hospitalized patients with acute severe ulcerative colitis. Bressler B. Can J Gastroenterol 2008. PMID: 19018340.
  24. Surgical management of acute colitis and toxic megacolon. Arnell TD. Clin Colon Rectal Surg 2004. PMID: 20011287.
  25. Rescue Diverting Loop Ileostomy: An Alternative to Emergent Colectomy in the Setting of Severe Acute Refractory IBD-Colitis. Russell TA. Dis Colon Rectum 2018. PMID: 29337777.
  26. Progression of flat low-grade dysplasia to advanced neoplasia in patients with ulcerative colitis. Ullman T. Gastroenterology 2003. PMID: 14598247.
  27. Management of Pouch Neoplasia. Sugita A. Dis Colon Rectum 2022. PMID: 35895865.
  28. Indications and Options for Surgery in Ulcerative Colitis. Bohl JL. Surg Clin North Am 2015. PMID: 26596923.
  29. Operative strategy modifies risk of pouch-related outcomes in patients with ulcerative colitis on preoperative anti-tumor necrosis factor-α therapy. Gu J. Dis Colon Rectum 2013. PMID: 24104999.
  30. Possible overuse of 3-stage procedures for active ulcerative colitis. Hicks CW. JAMA Surg 2013. PMID: 23700124.
  31. Modified Two-stage Ileal Pouch-Anal Anastomosis Results in Lower Rate of Anastomotic Leak Compared with Traditional Two-stage Surgery for Ulcerative Colitis. Zittan E. J Crohns Colitis 2016. PMID: 26951468.
  32. Modified-two-stage versus three-stage approach in ileoanal pouch surgery for ulcerative colitis. Moojen TB. J Crohns Colitis 2026. PMID: 41258995.
  33. Is diversion free ileal pouch-anal anastomosis a safe procedure? A meta-analysis of 4973 cases. Khan K. Int J Colorectal Dis 2021. PMID: 33398510.
  34. Minimally Invasive and Robotic Surgery for Ulcerative Colitis. Lee GC. Clin Colon Rectal Surg 2022. PMID: 36591398.
  35. Surgery for Inflammatory Bowel Disease in the Era of Biologics. Lightner AL. J Gastrointest Surg 2020. PMID: 32253646.
  36. The effect of restorative proctocolectomy on sexual function, urinary function, fertility, pregnancy and delivery: a systematic review. Cornish JA. Dis Colon Rectum 2007. PMID: 17588223.
  37. Does laparoscopic ileal pouch-anal anastomosis reduce infertility compared with open approach? Gorgun E. Surgery 2019. PMID: 31420214.
  38. Minimally invasive total proctocolectomy with Brooke ileostomy for ulcerative colitis. Holubar SD. Inflamm Bowel Dis 2009. PMID: 19266572.
  39. When Patients With IBD Require an Ostomy: Evidence-Based Answers to 10 Common Clinical Questions in IBD Surgery. Holubar SD. Am J Gastroenterol 2025. PMID: 39887123.
  40. Surgical treatment of ulcerative colitis: ileorectal vs ileal pouch-anal anastomosis. Scoglio D. World J Gastroenterol 2014. PMID: 25309058.
  41. The Fate of the Rectum in Inflammatory Bowel Disease. Savitch SL. Surg Clin North Am 2025. PMID: 40015825.
  42. Long-term outcome and quality of life after continent ileostomy for ulcerative colitis: A systematic review. Deputy M. Colorectal Dis 2021. PMID: 34166559.
  43. Continent Ileostomy as an Alternative to End Ileostomy. Wu XR. Gastroenterol Res Pract 2020. PMID: 32382274.
  44. Preoperative Corticosteroid Usage and Hypoalbuminemia Increase Occurrence of Short-term Postoperative Complications in Chinese Patients with Ulcerative Colitis. Li J. Chin Med J (Engl) 2016. PMID: 26879017.
  45. Postoperative Steroid Taper Is Associated With Pelvic Sepsis After Ileal Pouch-anal Anastomosis. Ritter KA. Inflamm Bowel Dis 2019. PMID: 30597024.
  46. Preoperative use of anti-TNF therapy and postoperative complications in inflammatory bowel diseases: a meta-analysis. Billioud V. J Crohns Colitis 2013. PMID: 23523418.
  47. A Multicentre Evaluation of Risk Factors for Anastomotic Leakage After Restorative Proctocolectomy with Ileal Pouch-Anal Anastomosis for Inflammatory Bowel Disease. Sahami S. J Crohns Colitis 2016. PMID: 26417046.
  48. Should ileoanal pouch surgery be staged for patients with mucosal ulcerative colitis on immunosuppressives? Zmora O. Int J Colorectal Dis 2007. PMID: 16932926.
  49. Preoperative infliximab is not associated with an increased risk of short-term postoperative complications after restorative proctocolectomy and ileal pouch-anal anastomosis. Gainsbury ML. J Gastrointest Surg 2011. PMID: 21246415.
  50. Tofacitinib Is Associated With Increased Risk of Postoperative Venous Thromboembolism in Patients With Ulcerative Colitis. Russell TA. Dis Colon Rectum 2024. PMID: 38231035.
  51. Postoperative Outcomes in Tofacitinib-Treated Patients With Acute Severe Ulcerative Colitis Undergoing Colectomy. Larson C. Clin Gastroenterol Hepatol 2025. PMID: 40239733.
  52. Prospective Cohort Study to Investigate the Safety of Preoperative Tumor Necrosis Factor Inhibitor Exposure in Patients With Inflammatory Bowel Disease Undergoing Intra-abdominal Surgery. Cohen BL. Gastroenterology 2022. PMID: 35413359.
  53. Biologics Before Surgery Are Not Associated With Complications After Surgery for IBD: A National Surgery Quality Improvement Program IBD Collaborative Causal Inference Analysis. Holubar SD. Dis Colon Rectum 2026. PMID: 41492952.