Top 100 Most Cited

The 100 most-cited papers across the ulcerative-colitis surgical and high-acuity literature, by citation count (NIH Open Citation Collection).

Ranked from the ulcerative-colitis surgical and high-acuity literature.

A research reference for clinicians and trainees: rankings are drawn from the published literature, not treatment advice. Always talk with your own care team about what any study means for you.

#PaperAltmetricCitations
1Ulcerative colitis.
Ungaro · 2017 · Lancet
2,898
2British Society of Gastroenterology consensus guidelines on the management of inflammatory bowel disease in adults.
Lamb · 2019 · Gut
1,838
3IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer.
Grivennikov S · 2009 · Cancer Cell
1,823
4Ulcerative colitis
Ordás · 2012 · Lancet
1,751
5Epidemiology and natural history of inflammatory bowel diseases.
Cosnes · 2011 · Gastroenterology
1,659
6Dysplasia in inflammatory bowel disease: standardized classification with provisional clinical applications.
Riddell · 1983 · Hum Pathol
1,590
7Third European Evidence-based Consensus on Diagnosis and Management of Ulcerative Colitis. Part 1: Definitions, Diagnosis, Extra-intestinal Manifestations, Pregnancy, Cancer Surveillance, Surgery, and Ileo-anal Pouch Disorders
Magro · 2017 · J Crohns Colitis
1,445
8Inflammatory bowel disease: clinical aspects and established and evolving therapies
Baumgart · 2007 · Lancet
1,444
9Ulcerative colitis and colorectal cancer. A population-based study.
Ekbom · 1990 · N Engl J Med
1,440
10Cyclosporine in severe ulcerative colitis refractory to steroid therapy.
Lichtiger · 1994 · N Engl J Med
1,435
11Ulcerative colitis
Kobayashi · 2020 · Nat Rev Dis Primers
1,351
12Ulcerative colitis.
Le Berre Catherine · 2023 · Lancet
1,219
13Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.
Anderson CA · 2011 · Nat Genet
1,079
14Oral bacteriotherapy as maintenance treatment in patients with chronic pouchitis: a double-blind, placebo-controlled trial
Gionchetti · 2000 · Gastroenterology
1,021
15Inflammation and cancer IV. Colorectal cancer in inflammatory bowel disease: the role of inflammation.
Itzkowitz SH · 2004 · Am J Physiol Gastrointest Liver Physiol
1,020
16Ileal pouch-anal anastomoses complications and function in 1005 patients
Fazio · 1995 · Ann Surg
959
17Mucosal healing in inflammatory bowel disease: results from a Norwegian population-based cohort.
Frøslie · 2007 · Gastroenterology
938
18Intestinal inflammation and cancer.
Ullman TA · 2011 · Gastroenterology
915
19Infliximab as rescue therapy in severe to moderately severe ulcerative colitis: a randomized, placebo-controlled study.
Järnerot · 2005 · Gastroenterology
833
20Early mucosal healing with infliximab is associated with improved long-term clinical outcomes in ulcerative colitis.
Colombel · 2011 · Gastroenterology
768
21Blocking TNF-alpha in mice reduces colorectal carcinogenesis associated with chronic colitis.
Popivanova BK · 2008 · J Clin Invest
756
22Prophylaxis of pouchitis onset with probiotic therapy: a double-blind, placebo-controlled trial
Gionchetti · 2003 · Gastroenterology
749
23Second European evidence-based consensus on the diagnosis and management of ulcerative colitis part 2: current management
Dignass · 2012 · J Crohns Colitis
735
24Risk of colorectal cancer in patients with ulcerative colitis: a meta-analysis of population-based cohort studies.
Jess · 2012 · Clin Gastroenterol Hepatol
731
25Edible ginger-derived nanoparticles: A novel therapeutic approach for the prevention and treatment of inflammatory bowel disease and colitis-associated cancer.
Zhang M · 2016 · Biomaterials
700
26Dysbiosis-Induced Secondary Bile Acid Deficiency Promotes Intestinal Inflammation
Sinha · 2020 · Cell Host Microbe
671
27Colorectal Cancer in Inflammatory Bowel Disease: Mechanisms and Management.
Shah SC · 2022 · Gastroenterology
656
28Methylene blue-aided chromoendoscopy for the detection of intraepithelial neoplasia and colon cancer in ulcerative colitis.
Kiesslich R · 2003 · Gastroenterology
650
29Histologic inflammation is a risk factor for progression to colorectal neoplasia in ulcerative colitis: a cohort study.
Gupta RB · 2007 · Gastroenterology
624
30European evidence based consensus for endoscopy in inflammatory bowel disease.
Annese Vito · 2013 · J Crohns Colitis
616
31Predicting outcome in severe ulcerative colitis.
Travis · 1996 · Gut
606
32Clinical course during the first 10 years of ulcerative colitis: results from a population-based inception cohort (IBSEN Study).
Solberg · 2009 · Scand J Gastroenterol
597
33Pouchitis after ileal pouch-anal anastomosis: a Pouchitis Disease Activity Index
Sandborn · 1994 · Mayo Clin Proc
585
34AGA Clinical Practice Guidelines on the Management of Moderate to Severe Ulcerative Colitis.
Feuerstein JD · 2020 · Gastroenterology
563
35Prevention of postoperative abdominal adhesions by a sodium hyaluronate-based bioresorbable membrane: a prospective, randomized, double-blind multicenter study
Becker · 1996 · J Am Coll Surg
545
36Ileal pouch anal anastomosis: analysis of outcome and quality of life in 3707 patients
Fazio · 2013 · Ann Surg
536
37Toll-like receptor-4 promotes the development of colitis-associated colorectal tumors.
Fukata M · 2007 · Gastroenterology
529
38Ulcerative Colitis in Adults: A Review.
Gros · 2023 · JAMA
527
39Course of ulcerative colitis: analysis of changes in disease activity over years.
Langholz · 1994 · Gastroenterology
526
40Response to corticosteroids in severe ulcerative colitis: a systematic review of the literature and a meta-regression.
Turner · 2007 · Clin Gastroenterol Hepatol
510
41Fecal microbiota transplant for treatment of Clostridium difficile infection in immunocompromised patients.
Kelly · 2014 · Am J Gastroenterol
500
42Ciclosporin versus infliximab in patients with severe ulcerative colitis refractory to intravenous steroids: a parallel, open-label randomised controlled trial.
Laharie · 2012 · Lancet
495
43Sphingosine-1-phosphate links persistent STAT3 activation, chronic intestinal inflammation, and development of colitis-associated cancer.
Liang J · 2013 · Cancer Cell
490
44Thirty-year analysis of a colonoscopic surveillance program for neoplasia in ulcerative colitis.
Rutter · 2006 · Gastroenterology
485
45A distinct subset of antineutrophil cytoplasmic antibodies is associated with inflammatory bowel disease.
Saxon · 1990 · J Allergy Clin Immunol
479
46Epithelial IL-18 Equilibrium Controls Barrier Function in Colitis.
Nowarski R · 2015 · Cell
477
47Altered tight junction structure contributes to the impaired epithelial barrier function in ulcerative colitis.
Schmitz · 1999 · Gastroenterology
469
48J ileal pouch-anal anastomosis for chronic ulcerative colitis: complications and long-term outcome in 1310 patients
Meagher · 1998 · Br J Surg
461
49European consensus on the diagnosis and management of iron deficiency and anaemia in inflammatory bowel diseases.
2015 · J Crohns Colitis
456
50Trough serum infliximab: a predictive factor of clinical outcome for infliximab treatment in acute ulcerative colitis.
Seow · 2010 · Gut
453
51Impact of Clostridium difficile on inflammatory bowel disease.
Issa · 2007 · Clin Gastroenterol Hepatol
452
52Are we telling patients the truth about surveillance colonoscopy in ulcerative colitis?
Bernstein · 1994 · Lancet
452
53Increased risk of colorectal neoplasia in patients with primary sclerosing cholangitis and ulcerative colitis: a meta-analysis.
2002 · Gastrointest Endosc
439
54Declining risk of colorectal cancer in inflammatory bowel disease: an updated meta-analysis of population-based cohort studies.
Lutgens · 2013 · Inflamm Bowel Dis
436
55A comprehensive review and update on ulcerative colitis.
Gajendran M · 2019 · Dis Mon
432
56Consensus conference: Colorectal cancer screening and surveillance in inflammatory bowel disease.
Itzkowitz · 2005 · Inflamm Bowel Dis
423
57Evidence-based clinical practice guidelines for inflammatory bowel disease
Matsuoka · 2018 · J Gastroenterol
398
58Ileal pouch-anal anastomosis for chronic ulcerative colitis. Long-term results
Pemberton · 1987 · Ann Surg
395
59Colorectal cancer risk and mortality in patients with ulcerative colitis.
Langholz · 1992 · Gastroenterology
394
60Randomised controlled trial of azathioprine and 5-aminosalicylic acid for treatment of steroid dependent ulcerative colitis.
Ardizzone · 2006 · Gut
391
61Ulcerative colitis and Crohn's disease: a comparison of the colorectal cancer risk in extensive colitis.
Gillen · 1994 · Gut
389
62Management of Paediatric Ulcerative Colitis, Part 1: Ambulatory Care-An Evidence-based Guideline From European Crohn's and Colitis Organization and European Society of Paediatric Gastroenterology, Hepatology and Nutrition
Turner · 2018 · J Pediatr Gastroenterol Nutr
387
63A comprehensive review and update on Crohn's disease.
Gajendran M · 2018 · Dis Mon
382
64C-reactive protein as a marker for inflammatory bowel disease.
Vermeire · 2004 · Inflamm Bowel Dis
380
65Precancer and cancer in extensive ulcerative colitis: findings among 401 patients over 22 years.
Lennard-Jones · 1990 · Gut
377
66Natural History of Adult Ulcerative Colitis in Population-based Cohorts: A Systematic Review.
Fumery · 2018 · Clin Gastroenterol Hepatol
375
67Greater risk of incisional hernia with morbidly obese than steroid-dependent patients and low recurrence with prefascial polypropylene mesh
Sugerman · 1996 · Am J Surg
371
68Pouchitis after ileal pouch-anal anastomosis for ulcerative colitis occurs with increased frequency in patients with associated primary sclerosing cholangitis
Penna · 1996 · Gut
371
69Long-term functional outcome and quality of life after stapled restorative proctocolectomy
Fazio · 1999 · Ann Surg
364
70Factors affecting the outcome of endoscopic surveillance for cancer in ulcerative colitis.
Connell · 1994 · Gastroenterology
364
71Mutations in the p53 gene: an early marker of neoplastic progression in ulcerative colitis.
Brentnall · 1994 · Gastroenterology
362
72Oxidative stress and ulcerative colitis-associated carcinogenesis: studies in humans and animal models.
Seril DN · 2003 · Carcinogenesis
357
73Beyond endoscopic mucosal healing in UC: histological remission better predicts corticosteroid use and hospitalisation over 6 years of follow-up.
Bryant · 2016 · Gut
357
74Colectomy rate comparison after treatment of ulcerative colitis with placebo or infliximab.
Sandborn · 2009 · Gastroenterology
355
75The London Position Statement of the World Congress of Gastroenterology on Biological Therapy for IBD with the European Crohn's and Colitis Organization: when to start, when to stop, which drug to choose, and how to predict response?
D'Haens GR · 2011 · Am J Gastroenterol
354
76A randomised dose finding study of oral tacrolimus (FK506) therapy in refractory ulcerative colitis.
Ogata · 2006 · Gut
353
77The Burden of Inflammatory Bowel Disease in Europe in 2020.
Zhao M · 2021 · J Crohns Colitis
349
78Infliximab in the treatment of severe, steroid-refractory ulcerative colitis: a pilot study.
Sands · 2001 · Inflamm Bowel Dis
348
79CX₃CR1⁺ mononuclear phagocytes support colitis-associated innate lymphoid cell production of IL-22.
Longman RS · 2014 · J Exp Med
335
80Randomized, double-blind comparison of 4 mg/kg versus 2 mg/kg intravenous cyclosporine in severe ulcerative colitis.
Van Assche · 2003 · Gastroenterology
330
81Modulation of the intestinal microbiota alters colitis-associated colorectal cancer susceptibility.
Uronis JM · 2009 · PLoS One
327
82The pattern and outcome of acute severe colitis.
Dinesen · 2010 · J Crohns Colitis
325
83Diagnosis and management of dysplasia in patients with inflammatory bowel diseases.
Itzkowitz Steven · 2004 · Gastroenterology
322
84Chronic ulcerative colitis and colorectal cancer
Rogler · 2014 · Cancer Lett
321
85Recent insights into the genetics of inflammatory bowel disease.
Cho JH · 2011 · Gastroenterology
321
86Intravenous cyclosporine versus intravenous corticosteroids as single therapy for severe attacks of ulcerative colitis.
D'Haens G · 2001 · Gastroenterology
320
87Pouchitis following ileal pouch-anal anastomosis: definition, pathogenesis, and treatment
Sandborn · 1994 · Gastroenterology
319
88Colorectal cancer and inflammatory bowel disease: epidemiology, risk factors, mechanisms of carcinogenesis and prevention strategies
Triantafillidis · 2009 · Anticancer Res
318
89Chronic intestinal inflammation: inflammatory bowel disease and colitis-associated colon cancer.
Rubin DC · 2012 · Front Immunol
316
90Changes in clinical characteristics, course, and prognosis of inflammatory bowel disease during the last 5 decades: a population-based study from Copenhagen, Denmark.
Jess · 2007 · Inflamm Bowel Dis
316
91East-West gradient in the incidence of inflammatory bowel disease in Europe: the ECCO-EpiCom inception cohort.
Burisch J · 2014 · Gut
312
92Advanced age is an independent risk factor for severe infections and mortality in patients given anti-tumor necrosis factor therapy for inflammatory bowel disease.
2011 · Clin Gastroenterol Hepatol
310
93Pouchitis and extraintestinal manifestations of inflammatory bowel disease after ileal pouch-anal anastomosis
Lohmuller · 1990 · Ann Surg
307
94Mucosal Healing Is Associated With Improved Long-term Outcomes of Patients With Ulcerative Colitis: A Systematic Review and Meta-analysis.
Shah · 2016 · Clin Gastroenterol Hepatol
305
95Clinical patterns, natural history, and progression of ulcerative colitis. A long-term follow-up of 1116 patients.
Farmer · 1993 · Dig Dis Sci
304
96Review article: the role of oxidative stress in pathogenesis and treatment of inflammatory bowel diseases.
Piechota-Polanczyk A · 2014 · Naunyn Schmiedebergs Arch Pharmacol
301
97An assessment of inflammation in the reservoir after restorative proctocolectomy with ileoanal ileal reservoir
Moskowitz · 1986 · Int J Colorectal Dis
300
98Results at up to 20 years after ileal pouch-anal anastomosis for chronic ulcerative colitis
Hahnloser · 2007 · Br J Surg
297
99Preliminary report: cyclosporin in treatment of severe active ulcerative colitis.
Lichtiger · 1990 · Lancet
295
100Natural history of elderly-onset inflammatory bowel disease: a population-based cohort study.
Charpentier · 2014 · Gut
295