Top 100 Most-Cited Papers

The 100 most-cited papers across the ulcerative-colitis surgical and high-acuity literature, by citation count (NIH Open Citation Collection).

A research reference for clinicians and trainees: rankings are drawn from the published literature, not treatment advice. Always talk with your own care team about what any study means for you.

Ungaro R · 2017 · Lancet · Ulcerative colitis.2,867 cites
Lamb CA · 2019 · Gut · British Society of Gastroenterology consensus guidelines on the management of inflammatory bowel disease in adults.1,824 cites
Grivennikov S · 2009 · Cancer Cell · IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer.1,815 cites
Ordás I · 2012 · Lancet · Ulcerative colitis.1,735 cites
Cosnes J · 2011 · Gastroenterology · Epidemiology and natural history of inflammatory bowel diseases.1,653 cites
Riddell RH · 1983 · Hum Pathol · Dysplasia in inflammatory bowel disease: standardized classification with provisional clinical applications.1,590 cites
Magro F · 2017 · J Crohns Colitis · Third European Evidence-based Consensus on Diagnosis and Management of Ulcerative Colitis. Part 1: Definitions, Diagnosis, Extra-intestinal Manifestations, Pregnancy, Cancer Surveillance, Surgery, and Ileo-anal Pouch Disorders.1,440 cites
Baumgart DC · 2007 · Lancet · Inflammatory bowel disease: clinical aspects and established and evolving therapies.1,440 cites
Ekbom A · 1990 · N Engl J Med · Ulcerative colitis and colorectal cancer. A population-based study.1,439 cites
Lichtiger S · 1994 · N Engl J Med · Cyclosporine in severe ulcerative colitis refractory to steroid therapy.1,433 cites
Kobayashi T · 2020 · Nat Rev Dis Primers · Ulcerative colitis.1,324 cites
Le Berre C · 2023 · Lancet · Ulcerative colitis.1,176 cites
Anderson CA · 2011 · Nat Genet · Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.1,078 cites
Gionchetti P · 2000 · Gastroenterology · Oral bacteriotherapy as maintenance treatment in patients with chronic pouchitis: a double-blind, placebo-controlled trial.1,021 cites
Itzkowitz SH · 2004 · Am J Physiol Gastrointest Liver Physiol · Inflammation and cancer IV. Colorectal cancer in inflammatory bowel disease: the role of inflammation.1,019 cites
Fazio VW · 1995 · Ann Surg · Ileal pouch-anal anastomoses complications and function in 1005 patients.958 cites
Frøslie KF · 2007 · Gastroenterology · Mucosal healing in inflammatory bowel disease: results from a Norwegian population-based cohort.936 cites
Ullman TA · 2011 · Gastroenterology · Intestinal inflammation and cancer.912 cites
Järnerot G · 2005 · Gastroenterology · Infliximab as rescue therapy in severe to moderately severe ulcerative colitis: a randomized, placebo-controlled study.831 cites
Colombel JF · 2011 · Gastroenterology · Early mucosal healing with infliximab is associated with improved long-term clinical outcomes in ulcerative colitis.766 cites
Popivanova BK · 2008 · J Clin Invest · Blocking TNF-alpha in mice reduces colorectal carcinogenesis associated with chronic colitis.755 cites
Gionchetti P · 2003 · Gastroenterology · Prophylaxis of pouchitis onset with probiotic therapy: a double-blind, placebo-controlled trial.748 cites
Dignass A · 2012 · J Crohns Colitis · Second European evidence-based consensus on the diagnosis and management of ulcerative colitis part 2: current management.735 cites
Jess T · 2012 · Clin Gastroenterol Hepatol · Risk of colorectal cancer in patients with ulcerative colitis: a meta-analysis of population-based cohort studies.722 cites
Zhang M · 2016 · Biomaterials · Edible ginger-derived nanoparticles: A novel therapeutic approach for the prevention and treatment of inflammatory bowel disease and colitis-associated cancer.687 cites
Sinha SR · 2020 · Cell Host Microbe · Dysbiosis-Induced Secondary Bile Acid Deficiency Promotes Intestinal Inflammation.661 cites
Kiesslich R · 2003 · Gastroenterology · Methylene blue-aided chromoendoscopy for the detection of intraepithelial neoplasia and colon cancer in ulcerative colitis.650 cites
Shah SC · 2022 · Gastroenterology · Colorectal Cancer in Inflammatory Bowel Disease: Mechanisms and Management.643 cites
Gupta RB · 2007 · Gastroenterology · Histologic inflammation is a risk factor for progression to colorectal neoplasia in ulcerative colitis: a cohort study.624 cites
Annese V · 2013 · J Crohns Colitis · European evidence based consensus for endoscopy in inflammatory bowel disease.612 cites
Travis SP · 1996 · Gut · Predicting outcome in severe ulcerative colitis.601 cites
Solberg IC · 2009 · Scand J Gastroenterol · Clinical course during the first 10 years of ulcerative colitis: results from a population-based inception cohort (IBSEN Study).594 cites
Sandborn WJ · 1994 · Mayo Clin Proc · Pouchitis after ileal pouch-anal anastomosis: a Pouchitis Disease Activity Index.584 cites
Feuerstein JD · 2020 · Gastroenterology · AGA Clinical Practice Guidelines on the Management of Moderate to Severe Ulcerative Colitis.557 cites
Becker JM · 1996 · J Am Coll Surg · Prevention of postoperative abdominal adhesions by a sodium hyaluronate-based bioresorbable membrane: a prospective, randomized, double-blind multicenter study.545 cites
Fazio VW · 2013 · Ann Surg · Ileal pouch anal anastomosis: analysis of outcome and quality of life in 3707 patients.535 cites
Fukata M · 2007 · Gastroenterology · Toll-like receptor-4 promotes the development of colitis-associated colorectal tumors.527 cites
Langholz E · 1994 · Gastroenterology · Course of ulcerative colitis: analysis of changes in disease activity over years.526 cites
Gros B · 2023 · JAMA · Ulcerative Colitis in Adults: A Review.515 cites
Turner D · 2007 · Clin Gastroenterol Hepatol · Response to corticosteroids in severe ulcerative colitis: a systematic review of the literature and a meta-regression.506 cites
Fallingborg J · 1999 · Dan Med Bull · Intraluminal pH of the human gastrointestinal tract.500 cites
Kelly CR · 2014 · Am J Gastroenterol · Fecal microbiota transplant for treatment of Clostridium difficile infection in immunocompromised patients.498 cites
Laharie D · 2012 · Lancet · Ciclosporin versus infliximab in patients with severe ulcerative colitis refractory to intravenous steroids: a parallel, open-label randomised controlled trial.492 cites
Liang J · 2013 · Cancer Cell · Sphingosine-1-phosphate links persistent STAT3 activation, chronic intestinal inflammation, and development of colitis-associated cancer.489 cites
Rutter MD · 2006 · Gastroenterology · Thirty-year analysis of a colonoscopic surveillance program for neoplasia in ulcerative colitis.485 cites
Saxon A · 1990 · J Allergy Clin Immunol · A distinct subset of antineutrophil cytoplasmic antibodies is associated with inflammatory bowel disease.479 cites
Nowarski R · 2015 · Cell · Epithelial IL-18 Equilibrium Controls Barrier Function in Colitis.471 cites
Schmitz H · 1999 · Gastroenterology · Altered tight junction structure contributes to the impaired epithelial barrier function in ulcerative colitis.467 cites
Meagher AP · 1998 · Br J Surg · J ileal pouch-anal anastomosis for chronic ulcerative colitis: complications and long-term outcome in 1310 patients.461 cites
Seow CH · 2010 · Gut · Trough serum infliximab: a predictive factor of clinical outcome for infliximab treatment in acute ulcerative colitis.453 cites
Bernstein CN · 1994 · Lancet · Are we telling patients the truth about surveillance colonoscopy in ulcerative colitis?452 cites
Issa M · 2007 · Clin Gastroenterol Hepatol · Impact of Clostridium difficile on inflammatory bowel disease.449 cites
Lutgens MW · 2013 · Inflamm Bowel Dis · Declining risk of colorectal cancer in inflammatory bowel disease: an updated meta-analysis of population-based cohort studies.434 cites
Gajendran M · 2019 · Dis Mon · A comprehensive review and update on ulcerative colitis.429 cites
Itzkowitz SH · 2005 · Inflamm Bowel Dis · Consensus conference: Colorectal cancer screening and surveillance in inflammatory bowel disease.423 cites
Matsuoka K · 2018 · J Gastroenterol · Evidence-based clinical practice guidelines for inflammatory bowel disease.396 cites
Pemberton JH · 1987 · Ann Surg · Ileal pouch-anal anastomosis for chronic ulcerative colitis. Long-term results.395 cites
Langholz E · 1992 · Gastroenterology · Colorectal cancer risk and mortality in patients with ulcerative colitis.394 cites
Ardizzone S · 2006 · Gut · Randomised controlled trial of azathioprine and 5-aminosalicylic acid for treatment of steroid dependent ulcerative colitis.391 cites
Gillen CD · 1994 · Gut · Ulcerative colitis and Crohn's disease: a comparison of the colorectal cancer risk in extensive colitis.389 cites
Turner D · 2018 · J Pediatr Gastroenterol Nutr · Management of Paediatric Ulcerative Colitis, Part 1: Ambulatory Care-An Evidence-based Guideline From European Crohn's and Colitis Organization and European Society of Paediatric Gastroenterology, Hepatology and Nutrition.382 cites
Gajendran M · 2018 · Dis Mon · A comprehensive review and update on Crohn's disease.379 cites
Vermeire S · 2004 · Inflamm Bowel Dis · C-reactive protein as a marker for inflammatory bowel disease.379 cites
Lennard-Jones JE · 1990 · Gut · Precancer and cancer in extensive ulcerative colitis: findings among 401 patients over 22 years.377 cites
Penna C · 1996 · Gut · Pouchitis after ileal pouch-anal anastomosis for ulcerative colitis occurs with increased frequency in patients with associated primary sclerosing cholangitis.371 cites
Sugerman HJ · 1996 · Am J Surg · Greater risk of incisional hernia with morbidly obese than steroid-dependent patients and low recurrence with prefascial polypropylene mesh.371 cites
Fumery M · 2018 · Clin Gastroenterol Hepatol · Natural History of Adult Ulcerative Colitis in Population-based Cohorts: A Systematic Review.368 cites
Fazio VW · 1999 · Ann Surg · Long-term functional outcome and quality of life after stapled restorative proctocolectomy.364 cites
Connell WR · 1994 · Gastroenterology · Factors affecting the outcome of endoscopic surveillance for cancer in ulcerative colitis.364 cites
Sugerman H · 1997 · J Intern Med · Intra-abdominal pressure, sagittal abdominal diameter and obesity comorbidity.363 cites
Brentnall TA · 1994 · Gastroenterology · Mutations in the p53 gene: an early marker of neoplastic progression in ulcerative colitis.363 cites
Seril DN · 2003 · Carcinogenesis · Oxidative stress and ulcerative colitis-associated carcinogenesis: studies in humans and animal models.356 cites
Sandborn WJ · 2009 · Gastroenterology · Colectomy rate comparison after treatment of ulcerative colitis with placebo or infliximab.355 cites
Bryant RV · 2016 · Gut · Beyond endoscopic mucosal healing in UC: histological remission better predicts corticosteroid use and hospitalisation over 6 years of follow-up.354 cites
D'Haens GR · 2011 · Am J Gastroenterol · The London Position Statement of the World Congress of Gastroenterology on Biological Therapy for IBD with the European Crohn's and Colitis Organization: when to start, when to stop, which drug to choose, and how to predict response?354 cites
Ogata H · 2006 · Gut · A randomised dose finding study of oral tacrolimus (FK506) therapy in refractory ulcerative colitis.352 cites
Sands BE · 2001 · Inflamm Bowel Dis · Infliximab in the treatment of severe, steroid-refractory ulcerative colitis: a pilot study.348 cites
Zhao M · 2021 · J Crohns Colitis · The Burden of Inflammatory Bowel Disease in Europe in 2020.343 cites
Longman RS · 2014 · J Exp Med · CX₃CR1⁺ mononuclear phagocytes support colitis-associated innate lymphoid cell production of IL-22.334 cites
Van Assche G · 2003 · Gastroenterology · Randomized, double-blind comparison of 4 mg/kg versus 2 mg/kg intravenous cyclosporine in severe ulcerative colitis.330 cites
Uronis JM · 2009 · PLoS One · Modulation of the intestinal microbiota alters colitis-associated colorectal cancer susceptibility.327 cites
Itzkowitz SH · 2004 · Gastroenterology · Diagnosis and management of dysplasia in patients with inflammatory bowel diseases.322 cites
Cho JH · 2011 · Gastroenterology · Recent insights into the genetics of inflammatory bowel disease.321 cites
Dinesen LC · 2010 · J Crohns Colitis · The pattern and outcome of acute severe colitis.321 cites
D'Haens G · 2001 · Gastroenterology · Intravenous cyclosporine versus intravenous corticosteroids as single therapy for severe attacks of ulcerative colitis.319 cites
Sandborn WJ · 1994 · Gastroenterology · Pouchitis following ileal pouch-anal anastomosis: definition, pathogenesis, and treatment.319 cites
Rogler G · 2014 · Cancer Lett · Chronic ulcerative colitis and colorectal cancer.318 cites
Triantafillidis JK · 2009 · Anticancer Res · Colorectal cancer and inflammatory bowel disease: epidemiology, risk factors, mechanisms of carcinogenesis and prevention strategies.316 cites
Jess T · 2007 · Inflamm Bowel Dis · Changes in clinical characteristics, course, and prognosis of inflammatory bowel disease during the last 5 decades: a population-based study from Copenhagen, Denmark.314 cites
Rubin DC · 2012 · Front Immunol · Chronic intestinal inflammation: inflammatory bowel disease and colitis-associated colon cancer.312 cites
Burisch J · 2014 · Gut · East-West gradient in the incidence of inflammatory bowel disease in Europe: the ECCO-EpiCom inception cohort.311 cites
Lohmuller JL · 1990 · Ann Surg · Pouchitis and extraintestinal manifestations of inflammatory bowel disease after ileal pouch-anal anastomosis.307 cites
Farmer RG · 1993 · Dig Dis Sci · Clinical patterns, natural history, and progression of ulcerative colitis. A long-term follow-up of 1116 patients.304 cites
Shah SC · 2016 · Clin Gastroenterol Hepatol · Mucosal Healing Is Associated With Improved Long-term Outcomes of Patients With Ulcerative Colitis: A Systematic Review and Meta-analysis.303 cites
Moskowitz RL · 1986 · Int J Colorectal Dis · An assessment of inflammation in the reservoir after restorative proctocolectomy with ileoanal ileal reservoir.300 cites
Piechota-Polanczyk A · 2014 · Naunyn Schmiedebergs Arch Pharmacol · Review article: the role of oxidative stress in pathogenesis and treatment of inflammatory bowel diseases.297 cites
Hahnloser D · 2007 · Br J Surg · Results at up to 20 years after ileal pouch-anal anastomosis for chronic ulcerative colitis.297 cites
Lichtiger S · 1990 · Lancet · Preliminary report: cyclosporin in treatment of severe active ulcerative colitis.294 cites
Charpentier C · 2014 · Gut · Natural history of elderly-onset inflammatory bowel disease: a population-based cohort study.293 cites
Cohen RD · 1999 · Am J Gastroenterol · Intravenous cyclosporin in ulcerative colitis: a five-year experience.286 cites