Does rectal mesalamine foam achieve better mucosal healing than oral mesalamine in adolescents with mild to moderate UC

What is known

- Adult data show that combined oral plus topical mesalamine is more effective than either alone for mucosal healing in mild-to-moderate ulcerative colitis. ^1,2 - Foam and liquid enema formulations are essentially equivalent to each other. ^1,3

What is unknown / caveats

- No retrieved study directly compares rectal mesalamine foam with oral mesalamine for mucosal healing in adolescents, so the question cannot be answered from this evidence. - The findings above are adult data, shown instead of adolescent-specific evidence.

## References

1. Bürger M, Schmidt C, Teich N, Stallmach A. Medical Therapy of Active Ulcerative Colitis. Viszeralmedizin. 2015. PMID: 26557831.

2. Dal Buono A, Roda G, Argollo M, Peyrin-Biroulet L, Danese S. Histological healing: should it be considered as a new outcome for ulcerative colitis?. Expert Opin Biol Ther. 2020;20(4):407-412. PMID: 31847610.

3. Singh S, Feuerstein JD, Binion DG, Tremaine WJ. AGA Technical Review on the Management of Mild-to-Moderate Ulcerative Colitis. Gastroenterology. 2019;156:769-808.e29. PMID: 30576642.

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_Draft, generated by the IBDology RAG and not yet clinician-reviewed. Answers are grounded in the retrieved literature listed above; a high faithfulness score means the answer matches its sources, not that the sources are correct._